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21.
Shahid Mahmood Baig Ayesha Azhar Hammad Hassan Jamshaid Mahmood Baig Muhammad Aslam Mohammad Amin Ud Din Javed Anver Qureshi Tariq Zaman 《黑龙江环境通报》2006,26(10):903-905
Pakistan has a large population of more than 150 million people with an overall carrier frequency of approximately 5.6% for β-thalassemia. Punjab is the largest province of the country having more than 50% of the population. The state of β-thalassemia is alarming as consanguinity is very high (>81%) and the literacy rate is low in South Punjab. A thalassemia prevention program is the need of the hour in this part of Pakistan. In this study, we initiated awareness, screening, and characterization of the mutations causing β-thalassemia as well as a genetic counseling program mainly in the districts of Faisalabad and D.G. Khan to establish prenatal diagnosis, a facility previously unavailable in this region for disease prevention. A total of 248 unrelated transfusion-dependent children and the available members of their families were screened to characterize the mutations and identify the carriers. Genetic counseling was provided to these families and prenatal diagnosis offered. In the samples analyzed, 11 β-thalassemia mutations and three hemoglobin variants were detected mainly by using the Monoplex and Multiplex ARMS-PCR. First-trimester prenatal diagnosis was carried out through chorionic villus sampling (CVS) in seven pregnancies at risk. As a result of our campaign, 145 carrier couples planning to have more children gave their consent to have retrospective prenatal diagnosis in every pregnancy in future. A cooperative trend and a positive attitude toward the prevention of β-thalassemia were noticed in the families with affected children and in the general population. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
22.
Ahmad Firoz Uddin Md Meraj Goparaju Laxmi Talukdar Nazimur Rahman Rizvi Javed 《Environment, Development and Sustainability》2021,23(10):15183-15203
Environment, Development and Sustainability - The study utilized the tree covers per cent, agroforestry suitability, present and future (2050) climate, agriculture vulnerability (2050), percentage... 相似文献
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Ahamed Maqusood Akhtar Mohd Javed Khan Mohd Abdul Majeed Alhadlaq Hisham Abdulaziz 《Environmental science and pollution research international》2021,28(14):17109-17118
Environmental Science and Pollution Research - Recent attention has been focused on reproductive toxicity of nanoscale materials in combination with pre-existing environmental pollutants. Due to... 相似文献
24.
Siddique Md Abu Bakar Islam Abu Reza Md Towfiqul Hossain Md Saddam Khan Rahat Akbor Md Ahedul Hasanuzzaman Md Sajid Md Wasiq Mamun Mia Md Younus Mallick Javed Rahman M. Safiur Rahman Md Mostafizur Bodrud-Doza Md 《Environmental science and pollution research international》2022,29(6):8577-8596
Environmental Science and Pollution Research - Currently, a well-developed combination of irrigation water quality index (IWQIs) and entropy water quality index (EWQIs) for surface water appraisal... 相似文献
25.
Fresh and healthy specimens of Oreochromis niloticus (mean weight 70.5± 1.23 g and mean length, 12.3± 1.5cm) and Clarias gariepinus (mean weight, 41.8±2.3 g and mean length 13.78 ± 1.2 cm) were exposed to heavy metal lead, ranging in concentration from 10 to 18 mg L‐1 for O. niloticus and 20 to 28 mg L‐1 for C. gariepinus respectively. The 96 h LC50 for both the species was computed as 12.45 mg L‐1 (O. niloticus) and 22.65 mg L‐1 (C. gariepinus). The cichlid fish was exposed to sublethal concentration of lead (2, 4 and 6 mgL‐1) and catfish (4, 8 and 12 mgL‐1). The erythrocytes count, haemoglobin concentration, haematocrit and the value of serum glucose increased significantly (P < 0.01), whereas leucocytes count, serum protein and serum triglyceride after intoxication declined in both the species with the same pattern but in different quantity. After 96 h of time a significant depletion of muscle and liver glycogen was noted, being greater in muscle (16.7% in O. niloticus) and in liver (15.9% in C. gariepinus). The response of fish to lead was dose dependent. 相似文献
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27.
Iftikhar Ahmad Muhammad Javed Akhtar Zahir Ahmad Zahir Muhammad Naveed Birgit Mitter Angela Sessitsch 《Environmental science and pollution research international》2014,21(18):11054-11065
Cadmium usually hampers plant growth, but bacterial inoculation may improve stress tolerance in plants to Cd by involving various mechanisms. The objective was to characterize and identify bacteria that improve plant growth under Cd stress and reduce Cd uptake. Cadmium-tolerant bacteria were isolated from rhizosphere soil, which was irrigated with tannery effluent, and six strains were selected as highly tolerant to Cd, showing minimum inhibitory concentration as 500 mg L?1 or 4.45 mmol L?1. These strains were identified by 16S rRNA gene analysis and functional analysis in regard to plant growth promotion characteristics. To determine their effect on cereal growth under Cd stress, seeds were inoculated with these strains individually and grown in soil contaminated with three Cd levels (0, 40 and 80 mg kg?1). Biomass production, relative water content (RWC), electrolyte leakage (ELL) and tissue Cd concentration were measured. Biomass of both cereals was inhibited strongly when exposed to Cd; however, bacterial inoculation significantly reduced the suppressive effect of Cd on cereal growth and physiology. The bacterial isolates belonged to the genera Klebsiella, Stenotrophomonas, Bacillus and Serratia. Maize was more sensitive than wheat to Cd. Klebsiella sp. strain CIK-502 had the most pronounced effects in promoting maize and wheat growth and lowering Cd uptake under Cd stress. 相似文献
28.
This study was carried out to find out the comparative distribution of heavy metals (Fe, Cu, Mn, Zn, Co, Cr, Cd and Pb) in various tissues (muscles, gills, liver, stomach and intestine) of Cyprinus carpio from Rawal Lake, Pakistan, during summer and winter. Relatively higher concentrations of Cd, Co, Cr, Cu, Fe and Zn were found in the stomach samples, while the highest Pb and Zn levels were noted in muscle and intestine samples, respectively. Correlation study exhibited diverse relationships among the metals in various tissues. Generally, the metal concentrations found during the summer were comparatively higher than the winter. Potential non-carcinogenic and carcinogenic health risks related to the metals in C. carpio were evaluated using the US Environmental Protection Agency approved cancer risk assessment guidelines. The calculated daily and weekly intakes of Pb, Cd, Cr and Co through the fish consumption were significantly higher than the permissible limits. In relation to the non-carcinogenic risks to human, Pb, Cd, Cr, Co and Zn levels were higher than the safe limits; however, carcinogenic risks related to Cr (3.9?×?10?3 during summer and 1.1?×?10?3 during winter) and Pb (2.6?×?10?4 during summer and 1.5?×?10-4 during winter) clearly exceeded the safe limit (1?×?10?6). Consequently, the consumption of C. carpio from Rawal Lake on regular basis was considered unsafe. 相似文献
29.
Ahmad I Siddiqui H Akhtar MJ Khan MI Patil G Ashquin M Patel DK Arif JM 《Chemosphere》2011,83(4):455-460
In this in vitro study we investigated the toxic responses in hepatocytes treated with occupational dust to which workers are exposed in bone-based industrial units. The present study investigated the toxicity mechanism of bone-based occupational dust, from a particular industrial unit, on isolated rat hepatocytes. The hepatocytes were isolated by collagenase perfusion method and cell viability was determined by trypan blue exclusion and MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay treated with occupational dust at 0.1-1.0 mgmL(-1), for 120 min. The cell viability decreased significantly in a concentration-dependent manner. Dust induced significant membrane damage measured by lactate dehydrogenase (LDH) and glutathione (GSH) release in culture media for 30-, 60- and 120 min treatment duration. The toxicity was found to be correlated with the induction of lipid peroxidation (LPO). In addition, nitric oxide (NO), and hydrogen peroxide (H(2)O(2)) generation by occupational dusts were also found to be time- and concentration-dependent. Over all the present study provides initial evidences for the toxic potential of occupational dust generated in bone-based industries and, therefore, the dust exposure to workers in unorganized industrial units should be controlled. 相似文献
30.
Neeta Thacker Javed Sheikh S. M. Tamane Anil Bhanarkar Deepanjan Majumdar Kanchan Singh Chatrapati Chavhan Jitendra Trivedi 《Environmental monitoring and assessment》2013,185(1):425-429
This study investigated dioxins and dioxin-like polychlorinated biphenyls in gasses emitted from waste incinerators and thermal processes in central and western parts of India. The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs/DFs) ranged from 0.0070 to 26.8140 ng toxicity equivalent (TEQ)/Nm3, and those of dioxin-like polychlorinated biphenyls (PCBs) ranged from 0.0001?×?10?1 to 0.0295 ng TEQ/Nm3. The characteristics of mean PCDD/F I-TEQ concentration and congener profiles were studied over all the samples of air. In particular, a pattern consisting of a low proportion of dioxin-like PCBs and high proportion of PCDDs/DFs was common for all the samples from incinerators and high-temperature processes. 相似文献